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내용보기 Polyethylene Glycols (PEG)
Reagents for Pegylation
PEGs possess a variety of properties pertinent to biomedical and biotechnical applications.
A summary of some properties of interest is given here:
- Soluble in water, toluene, methylene chloride, many organic solvents.
- Insoluble in ethyl ether, hexane, ethylene glycol.
- Insoluble in water at elevated temperature.
- Solubility and partitioning controlled by making derivatives.
- Forms complexes with metal cations.
- Highly mobile; large exclusion volume in water.
- Can be used to precipitate proteins and nucleic acids.
- Forms two-phase systems with aqueous solutions of other polymers.
- Nontoxic; FDA approved for internal consumption.
- Hospitable to biological materials.
- Causes cell fusion (in high concentration).
- Weakly immunogenic.
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